PN Newest – Polynucleotide Skinbooster Singapore
PN Newest is a skinbooster treatment that uses highly purified polynucleotides (naturally derived DNA fragments) to stimulate the skin’s own regenerative processes, promoting collagen and elastin synthesis, improving cellular metabolism, and enhancing the skin’s capacity to repair and renew itself.
When injected into the skin, polynucleotides are recognised by the body’s own cells as growth signals, activating fibroblasts and enhancing the skin’s natural regenerative pathways. PN Newest is the updated formulation combining highly purified polynucleotides with hyaluronic acid – giving it both the regenerative action of polynucleotide stimulation and the immediate hydration benefit of HA.
How PN Newest Works
- Fibroblast activation: PN signals fibroblasts to increase collagen and elastin production
- Cellular metabolism enhancement: PN fragments enhance DNA and RNA synthesis in skin cells, improving overall cellular health and repair capacity
- Tissue repair signalling: polynucleotides promote expression of growth factors involved in skin repair
- Anti-inflammatory effect: polynucleotides have a documented anti-inflammatory action – particularly relevant for reactive or rosacea-prone skin
- Hydration: the hyaluronic acid component provides additional intradermal hydration alongside the regenerative effect
What PN Newest Addresses
- Skin thinning and loss of density – particularly relevant in perimenopausal and postpartum skin
- Dullness, uneven tone, and loss of natural skin luminosity
- Fine lines and surface texture irregularities
- Reactive or compromised skin that needs structural rebuilding
- Acne scars and mild textural scarring
What You Can Expect to See
- Progressively more even skin tone and refined texture with each course of treatment
- Skin that recovers more quickly from stress, sun exposure, or breakouts
- A healthier-looking complexion – not a dramatic change, but a genuine improvement in skin quality
- Reduced post-acne discolouration and marks
- Firmer, more resilient skin
Not Sure if PN Newest is the Right Treatment For You?
Speak to our doctor
Dr Sue Ho
Aesthetic Doctor, Special Interest in Women’s Health
Lead Doctor, Women’s Health | MB BCH BAO (Ireland)
Dr Sue is an internationally trained doctor with a clinical focus on postpartum recovery, perimenopause, and menopause. As a mother herself, she understands the changes women navigate at each stage of life. She will listen, assess, and give you an honest picture of your options.
What Your PN Newest Journey Looks Like
During treatment
Topical numbing cream applied. PN Newest delivered as a series of intradermal injections. Sessions take approximately 15 to 20 minutes. Mild redness and small injection points resolve within 24 to 48 hours.
After treatment
Minimal downtime. Mild redness and small injection points typically resolve within 24 to 48 hours. Normal activities can be resumed the same day.
Results and treatment schedule
Visible improvement in skin texture, tone, and radiance at around 2 to 4 weeks from the start of treatment, with continued improvement over subsequent months. Initial course of 3 to 4 sessions spaced 2 to 4 weeks apart. Maintenance sessions every 3 to 6 months. Results are cumulative across sessions.
How Much Does PN Newest Cost at Prologue?
PN Newest starts from $700 per session. The final cost depends on your skin condition, the number of sessions recommended, and the extent of treatment required – all of which are assessed and discussed during your consultation before any commitment is made.
FAQ
How is PN Newest different from HTIC Collagen Skinbooster?
HTIC delivers exogenous Type I collagen as a biological scaffold and direct collagen precursor. PN Newest uses polynucleotides to activate the skin’s own cellular regeneration pathways at a DNA/RNA level. Both stimulate collagen through different mechanisms and can be used together as part of a comprehensive programme. Dr Sue will advise on which is most appropriate for your specific concerns.
Is PN Newest suitable for sensitive skin?
Yes. Polynucleotides have an anti-inflammatory action and are generally well-tolerated by reactive or sensitive skin. The product is derived from highly purified trout DNA and is not recommended for patients with a confirmed allergy to fish or fish products – this is discussed at consultation.
How many sessions do I need?
An initial course of 3 to 4 sessions spaced 2 to 4 weeks apart is standard. Because polynucleotide results are cumulative and build progressively, completing the initial course is important for seeing the full benefit.
I am pregnant. Can I do PN Newest?
We do not perform this treatment during pregnancy. This is a precautionary measure to ensure your safety and your baby’s and not a reflection of the treatment’s risk profile in general. If you are currently pregnant and looking for support, we offer a range of women’s wellness services to support you through your pregnancy journey. Please reach out and we will point you in the right direction.
Is this treatment safe for breastfeeding mothers?
Yes. This treatment is considered safe for women who are breastfeeding. If you have any specific concerns, please mention this at your consultation and our doctor will advise accordingly.
How many months postpartum do I need to be before starting this treatment?
We recommend waiting until at least 6 months postpartum before beginning treatment. This allows your body adequate time to recover from delivery and for your hormone levels to begin stabilising – both of which influence how your skin responds to treatment and the results you can expect.