RSV Vaccine in Singapore – For Pregnant Women and Adults

Same Day Appointment Available

Only RSV Vaccine in Singapore Approved for Use in Pregnancy

$320 per dose — a single injection given between 32 and 36 weeks

Prologue Clinic carries the only RSV vaccine in Singapore approved for use during pregnancy. Vaccinating between 32 and 36 weeks gives your body time to build antibodies and pass them to your baby before delivery.

What Is The RSV Vaccine?

The RSV vaccine is a single-dose vaccination that helps protect against Respiratory Syncytial Virus (RSV), a common respiratory virus that can cause bronchiolitis and pneumonia in infants and older adults. As there is no specific antiviral treatment for RSV infection, vaccination is the most effective form of prevention.

At Prologue Clinic, we offer the only RSV vaccine in Singapore approved for use during pregnancy. Adults aged 60 and older, or those 18 and above with certain chronic conditions, including lung disease, heart disease, and diabetes, regardless of being pregnant or not, may also be eligible for vaccination.

How Does the RSV Vaccine Protect My Baby During Pregnancy?

When a pregnant woman is vaccinated, her immune system produces antibodies against RSV. These antibodies cross the placenta and are transferred to the baby before birth, helping to protect the newborn during the first few months of life, when their immune system is still developing.

Clinical studies have shown that vaccination during 32 to 36 weeks of pregnancy can significantly reduce the risk of severe RSV-related illness in infants:

  • Approximately 91% reduction in the risk of severe RSV lower respiratory tract illness within the first 3 months of life 
  • Approximately 77% reduction within the first 6 months of life 

 

Protection against all RSV lower respiratory tract illness, including milder cases, is lower – around 35% at 3 months and 57% at 6 months. This indicates that the vaccine’s strongest benefit is in reducing the risk of severe illness that may require medical care.

When to Get RSV Vaccine in Pregnancy

Pregnant women are encouraged to get the RSV vaccine between 32 and 36 weeks. This gives antibodies enough time to cross the placenta before delivery.


In Singapore, RSV circulates year-round – there is no seasonal window to wait for. The vaccine can be co-administered with the influenza and Tdap vaccines typically given in the third trimester.

Why Do Adults Over 60 Need the RSV Vaccine?

As the immune system weakens with age, RSV is more likely to progress to serious lower respiratory tract disease, particularly in those with Chronic Obstructive Pulmonary Disease (COPD), heart disease, or diabetes.

The RSV vaccine significantly reduces this risk. In a clinical trial of over 34,000 adults aged 60 and older, it reduced the risk of serious RSV lung infections by 88.9% in the first season and 81.5% across two consecutive seasons. 

A separate real-world study of over 131,000 adults aged 60 and older, found the RSV vaccine cut RSV-related hospital admissions by 83.3%, and admissions specifically for serious lung infections by 91.7%.

Is the RSV Vaccine Safe?

The RSV vaccine has been evaluated in clinical trials and approved for use in pregnant women and older adults. Side effects are generally mild and temporary.

In pregnant women, common side effects include injection site soreness, headache, muscle aches, and nausea. Some studies found a slightly higher rate of certain blood pressure-related conditions, but they did not find an increase in babies being born early. 

Health authorities consider the vaccine appropriate for use at 32 to 36 weeks of gestation, where the benefits to the baby outweigh potential risks. Those with a history of blood pressure complications in pregnancy should consult their doctor.

In adults aged 60 and above, side effects are usually mild and may include fatigue, headache, muscle aches, and a sore arm, similar to what you might feel after a flu jab.

Rare cases of a neurological condition causing temporary muscle weakness (such as Guillain-Barré syndrome) have been reported in older adults, and most people recover fully. Individuals with a history of similar conditions should speak with their doctor before vaccination.

RSV Vaccine Dose and Schedule

The RSV vaccine is given as a single-dose injection into the upper arm. For adults aged 60 and above, vaccination can be given at any time of the year.

A booster dose is not currently required.

RSV Vaccine Cost in Singapore

Vaccination

Price*

RSV vaccine — for pregnant women and adults 60+

$320 / dose

[Optional] Influenza vaccine

$40 / dose

[Optional] Tdap — tetanus, diphtheria and whooping cough

~$59 / dose

Other vaccinations

Please enquire

*Prices are before GST. Contact us to confirm the latest rates before your visit.

Why Get Vaccinated at Prologue Clinic

Women’s health specialists

Prologue Clinic doctors specialise in pregnancy, postpartum, and midlife care, offering vaccination advice within the context of your overall health.

Comfortable, calm environment

Relax in a comfortable setting designed to help you feel at ease throughout your visit.

A gentle vaccination experience

We understand that pregnancy can make you more sensitive to discomfort. Our doctors take a gentle, reassuring approach to every vaccination.

Frequently Asked Questions

Can I get the RSV vaccine while pregnant?

Yes. The RSV vaccine we carry is the only RSV vaccine in Singapore approved for use during pregnancy, given as a single injection between 32 and 36 weeks.

Between 32 and 36 weeks, which gives protective antibodies enough time to develop and transfer to your baby before birth.

Clinical data did not show a statistically significant increase in preterm birth rates, and health authorities have concluded that the benefits of vaccination at 32 to 36 weeks outweigh the potential risks.

If not pregnant, the RSV vaccine is primarily recommended for adults aged 60 and above, or adults aged 50 to 59 with certain chronic conditions. If you are younger and in good health, it is not currently routinely recommended. Speak to your doctor if you have specific concerns.

In older adults, RSV can progress to bronchitis or pneumonia and may worsen existing conditions like COPD or heart disease, sometimes requiring hospitalisation.

Routine vaccination is recommended from age 60, though adults aged 50 to 59 with certain chronic conditions are also eligible.

The RSV vaccine is given to the mother during pregnancy so antibodies transfer to the baby before birth, while the RSV antibody injection is given directly to the newborn after birth. Both can be used together.

For adults, protection is maintained across at least two years, for babies, maternal antibodies remain effective for approximately six months.

Side effects are generally mild. The most common are soreness at the injection site, headache, fatigue, and muscle aches, usually resolving within a day or two.

No. The RSV vaccine is not currently Medisave-claimable and there is no government subsidy in Singapore.

This depends on your policy. The clinic can provide official documentation to support your insurance reimbursement claim.

The maternal RSV vaccine works by transferring antibodies during pregnancy, so it should be given at 32 to 36 weeks of each pregnancy rather than in advance.

Babies protected through maternal vaccination carry protective antibodies for approximately six months – the window when they are most vulnerable to serious RSV illness.

The RSV vaccine is available at selected polyclinics across Singapore. At Prologue Clinic, the RSV vaccine we carry is approved for adults aged 60 and above and for pregnant women. Vaccines can be administered fast as there is no long wait and same-day appointments are available. Contact us to ask about subsidies you may be eligible for.

Breast milk contains antibodies and immune factors that offer some general protection against infections in early infancy. However, it does not specifically prevent RSV, and breastfed babies can and do contract the virus.

Simple measures instead reduce the risk: frequent hand washing before handling a newborn, keeping babies away from people with respiratory symptoms, avoiding crowded indoor spaces in the early weeks, and cleaning surfaces regularly – as RSV can survive on surfaces for several hours.

However, there is no guaranteed way to prevent RSV through hygiene measures alone. The virus spreads easily, and many infections come from family members with only mild symptoms.

References

ABRYSVO Prescribing Information, Singapore; Jul 2024. Kampmann B, et al. N Engl J Med. 2023;388:1451–1464.

Walsh EE, Pérez Marc G, Falsey AR, Jiang Q, Eiras D, Patton M, Polack FP, Llapur C, Doreski PA, Zareba AM, Ilangovan K, Rämet M, Fukushima Y, Hussen N, Bont LJ, Cardona J, DeHaan E, Mikati T, Shah RN, Schneider K, Cooper D, Koury K, Lino MM, Anderson AS, Jansen KU, Swanson KA, Gruber WC, Schmoele-Thoma B, Gurtman A. RENOIR Trial – RSVpreF Vaccine Efficacy over Two Seasons. N Engl J Med. 2024 Oct 17;391(15):1459-1460. doi: 10.1056/NEJMc2311560. PMID: 39413383.

Lassen MCH, et al. N En gl J Me d. 2 0 2 5.

Michnick AI, MacDonald SC, Adimadhyam S, Zhang F, Cosgrove A, Petrone AB, Round KE, Gandhi S, Koram N, Anastasiou OE, Rubino H, Lino MM, Djibo DA, Kuntz JL, Love SM, McMahill-Walraven CN, Palmsten K, Wentz AE, Andrade SE, Platt R, Maro JC. Sequential Safety Surveillance of RSVpreF Vaccination During Pregnancy Early in the Postapproval Period. JAMA Netw Open. 2026 Apr 1;9(4):e266190. doi: 10.1001/jamanetworkopen.2026.6190. Erratum in: JAMA Netw Open. 2026 May 1;9(5):e2617937. doi: 10.1001/jamanetworkopen.2026.17937. PMID: 42012833; PMCID: PMC13100873.

Fleming-Dutra KE, Jones JM, Roper LE, Prill MM, Ortega-Sanchez IR, Moulia DL, Wallace M, Godfrey M, Broder KR, Tepper NK, Brooks O, Sánchez PJ, Kotton CN, Mahon BE, Long SS, McMorrow ML. Use of the Pfizer Respiratory Syncytial Virus Vaccine During Pregnancy for the Prevention of Respiratory Syncytial Virus-Associated Lower Respiratory Tract Disease in Infants: Recommendations of the Advisory Committee on Immunization Practices – United States, 2023. MMWR Morb Mortal Wkly Rep. 2023 Oct 13;72(41):1115-1122. doi: 10.15585/mmwr.mm7241e1. PMID: 37824423; PMCID: PMC10578951.

Cullen LA, Gibbons CL, Shi T, Hasan T, Sullivan C, Marsh K, Robertson C, Cameron JC, Ghebrehewet S. RSV Vaccination Programme for Older Adults: A Scotland-Wide Study on RSVpreF Vaccine Safety. Vaccines (Basel). 2025 Oct 24;13(11):1088. doi: 10.3390/vaccines13111088. PMID: 41295461; PMCID: PMC12656231.

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